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  1. Original research

    Genetic diversity of Leishmania amazonensisstrains isolated in northeastern Brazil as revealed by DNA sequencing, PCR-based analyses and molecular karyotyping

    Leishmania (Leishmania) amazonensis infection in man results in a clinical spectrum of disease manifestations ranging from cutaneous to mucosal or visceral involvement. In the present study, we have investigated ...

    João Paulo C de Oliveira, Flora Fernandes, Angela K Cruz, Viviane Trombela, Elisângela Monteiro, Anamaria A Camargo, Aldina Barral and Camila I de Oliveira

    Kinetoplastid Biology and Disease 2007 6:5

    Published on: 21 June 2007

  2. Original research

    Dynamics of infection and competition between two strains of Trypanosoma brucei bruceiin the tsetse fly observed using fluorescent markers

    Genetic exchange occurs between Trypanosoma brucei strains during the complex developmental cycle in the tsetse vector, probably within the salivary glands. Successful mating will depend on the dynamics of co-inf...

    Lori Peacock, Vanessa Ferris, Mick Bailey and Wendy Gibson

    Kinetoplastid Biology and Disease 2007 6:4

    Published on: 6 June 2007

  3. Review

    Consultative meeting to develop a strategy for treatment of cutaneous leishmaniasis. Institute Pasteur, Paris. 13–15 June, 2006

    A meeting was organized by Drugs for Neglected Diseases initiative (DNDi) and the Institute Pasteur (IP), Paris, to review the treatment for all forms of cutaneous leishmaniasis (CL) and to propose a strategy ...

    Farrokh Modabber, Pierre A Buffet, Els Torreele, Geneviéve Milon and Simon L Croft

    Kinetoplastid Biology and Disease 2007 6:3

    Published on: 24 April 2007

  4. Original research

    The cysteine proteinase inhibitor Z-Phe-Ala-CHN2 alters cell morphology and cell division activity of Trypanosoma brucei bloodstream forms in vivo

    Current chemotherapy of human African trypanosomiasis or sleeping sickness relies on drugs developed decades ago, some of which show toxic side effects. One promising line of research towards the development o...

    Stefan Scory, York-Dieter Stierhof, Conor R Caffrey and Dietmar Steverding

    Kinetoplastid Biology and Disease 2007 6:2

    Published on: 28 February 2007

  5. Focus

    Leishmaniaamastigotes as targets for drug screening

    Direct drug screening against the mammalian stage of Leishmania has been hampered by cost and the time consuming effort required to accomplish it. The ability to derive transgenic Leishmania expressing reporter g...

    Adriano Monte-Alegre, Ali Ouaissi and Denis Sereno

    Kinetoplastid Biology and Disease 2006 5:6

    Published on: 23 October 2006

  6. Focus

    Highlights of the XXI annual meeting of the Brazilian Society of Protozoology, the XXXII annual meeting on Basic Research in Chagas' disease & an international symposium on vesicle trafficking in parasitic Protozoa – 7 to 9 November 2005, Caxambu, Minas Gerais, Brazil

    This report focuses on the 2005 Annual meeting held in Caxambu, Minas Gerais, Brazil that was convened and organized by the Brazilian Society of Protozoology

    Jeffrey Shaw, Sergio Schenkman and Mauricio Martins Rodrigues

    Kinetoplastid Biology and Disease 2006 5:4

    Published on: 17 August 2006

  7. Original research

    LmxMPK4, a mitogen-activated protein (MAP) kinase homologue essential for promastigotes and amastigotes of Leishmania mexicana

    Leishmania parasites undergo profound morphological and biochemical changes while passing through their life cycle. Protein kinases have been shown to be involved in the differentiation from the extracellular fla...

    Qiong Wang, Inga M Melzer, Martin Kruse, Claudia Sander-Juelch and Martin Wiese

    Kinetoplastid Biology and Disease 2005 4:6

    Published on: 29 December 2005

  8. Original research

    Detection of trypanosomes in small ruminants and pigs in western Kenya: important reservoirs in the epidemiology of sleeping sickness?

    Trypanosomosis is a major impediment to livestock farming in sub-Saharan Africa and limits the full potential of agricultural development in the 36 countries where it is endemic. In man, sleeping sickness is f...

    Musa O Ng'ayo, Zablon K Njiru, Eucharia U Kenya, Geoffrey M Muluvi, Ellie O Osir and Daniel K Masiga

    Kinetoplastid Biology and Disease 2005 4:5

    Published on: 14 July 2005

  9. Original research

    Application of Direct Agglutination Test (DAT) and Fast Agglutination Screening Test (FAST) for sero-diagnosis of visceral leishmaniasis in endemic area of Minas Gerais, Brazil

    The direct agglutination test (DAT) has proved to be a very important sero-diagnostic tool combining high levels of intrinsic validity and ease of performance. Otherwise, fast agglutination screening test (FAS...

    Eduardo S Silva, Gerard J Schoone, Celia MF Gontijo, Reginaldo P Brazil, Raquel S Pacheco and Henk DFH Schallig

    Kinetoplastid Biology and Disease 2005 4:4

    Published on: 14 June 2005

  10. Original research

    Adoptive transfer of dendritic cells modulates immunogenesis and tolerogenesis in a neonatal model of murine cutaneous leishmaniasis

    We evaluated the adoptive transfer of DCs on Leishmania (L.) mexicana-infected neonatal BALB/c mice. DCs were isolated and purified from the spleens of the following donor groups: a) Adult BALB/c mice infected du...

    Loida V Ponce, José Corado, Nilka L Díaz and Felix J Tapia

    Kinetoplastid Biology and Disease 2005 4:2

    Published on: 25 January 2005

  11. Original research

    Experimental study of the function of the excreted/secreted LeishmaniaLmSIR2 protein by heterologous expression in eukaryotic cell line

    In yeast and Caenorhabditis elegans, Silent Information Regulator (SIR2) proteins have been shown to be involved in ageing regulation. In Leishmania, the LmSIR2rp was originally isolated from the excreted/secrete...

    Denis Sereno, Laurent Vanhille, Baptiste Vergnes, Adriano Monte-Allegre and Ali Ouaissi

    Kinetoplastid Biology and Disease 2005 4:1

    Published on: 24 January 2005

  12. Original research

    Variable Surface Glycoprotein RoTat 1.2 PCR as a specific diagnostic tool for the detection of Trypanosoma evansiinfections

    Based on the recently sequenced gene coding for the Trypanosoma evansi (T. evansi) RoTat 1.2 Variable Surface Glycoprotein (VSG), a primer pair was designed targeting the DNA region lacking homology to other know...

    Filip Claes, Magda Radwanska, Toyo Urakawa, Phelix AO Majiwa, Bruno Goddeeris and Philip Büscher

    Kinetoplastid Biology and Disease 2004 3:3

    Published on: 17 September 2004

  13. Review

    Chagas' disease and AIDS

    Chagas' disease caused by Trypanosoma cruzi is an opportunistic infection in the setting of HIV/AIDS. Some individuals with HIV and chronic T. cruzi infection may experience a reactivation, which is most commonly...

    Anil K Vaidian, Louis M Weiss and Herbert B Tanowitz

    Kinetoplastid Biology and Disease 2004 3:2

    Published on: 13 May 2004

  14. Focus

    Trypanosoma rangeliTranscriptome Project: Generation and analysis of expressed sequence tags

    Trypanosoma rangeli is an important hemoflagellate parasite of several mammalian species in Central and South America, sharing geographical areas, vectors and reservoirs with T. cruzi, the causative agent of Chag...

    Cristiane Quimelli Snoeijer, Gisele Fernanda Picchi, Bibiana Paula Dambrós, Mário Steindel, Samuel Goldenberg, Stênio Perdigão Fragoso, Daniel Macedo Lorenzini and Edmundo Carlos Grisard

    Kinetoplastid Biology and Disease 2004 3:1

    Published on: 13 May 2004

  15. Focus

    Concepts of species in trypanosomatids

    This paper is a commentary on "Species concepts for trypanosomes: from morphological to molecular definitions?" by Wendy Gibson published in this journal [1]. Taxonomy has been traditionally based on expert opini...

    Hooman Momen

    Kinetoplastid Biology and Disease 2003 2:13

    Published on: 28 October 2003

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