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  1. Protozoan parasites improve the likelihood of invading or adapting to the host through their capacity to present a large repertoire of surface molecules. The understanding of the mechanisms underlying the gene...

    Authors: Francisco J Azuaje, Jose L Ramirez and Jose F Da Silveira

    Citation: Kinetoplastid Biology and Disease 2007 6:6

    Content type: Original research

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  2. Leishmania (Leishmania) amazonensis infection in man results in a clinical spectrum of disease manifestations ranging from cutaneous to mucosal or visceral involvement. In the present study, we have investigated ...

    Authors: João Paulo C de Oliveira, Flora Fernandes, Angela K Cruz, Viviane Trombela, Elisângela Monteiro, Anamaria A Camargo, Aldina Barral and Camila I de Oliveira

    Citation: Kinetoplastid Biology and Disease 2007 6:5

    Content type: Original research

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  3. Genetic exchange occurs between Trypanosoma brucei strains during the complex developmental cycle in the tsetse vector, probably within the salivary glands. Successful mating will depend on the dynamics of co-inf...

    Authors: Lori Peacock, Vanessa Ferris, Mick Bailey and Wendy Gibson

    Citation: Kinetoplastid Biology and Disease 2007 6:4

    Content type: Original research

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  4. A meeting was organized by Drugs for Neglected Diseases initiative (DNDi) and the Institute Pasteur (IP), Paris, to review the treatment for all forms of cutaneous leishmaniasis (CL) and to propose a strategy ...

    Authors: Farrokh Modabber, Pierre A Buffet, Els Torreele, Geneviéve Milon and Simon L Croft

    Citation: Kinetoplastid Biology and Disease 2007 6:3

    Content type: Review

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  5. Current chemotherapy of human African trypanosomiasis or sleeping sickness relies on drugs developed decades ago, some of which show toxic side effects. One promising line of research towards the development o...

    Authors: Stefan Scory, York-Dieter Stierhof, Conor R Caffrey and Dietmar Steverding

    Citation: Kinetoplastid Biology and Disease 2007 6:2

    Content type: Original research

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  6. In a SINE-based PCR assay, a primer set specific for guinea pig genome short interspersed elements DNA was used to test the utility of genomic markers for identifying the source of vertebrate blood meals of Triat...

    Authors: Juan Carlos Pizarro, David Lucero and Lori Stevens

    Citation: Kinetoplastid Biology and Disease 2007 6:1

    Content type: Original research

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  7. Direct drug screening against the mammalian stage of Leishmania has been hampered by cost and the time consuming effort required to accomplish it. The ability to derive transgenic Leishmania expressing reporter g...

    Authors: Adriano Monte-Alegre, Ali Ouaissi and Denis Sereno

    Citation: Kinetoplastid Biology and Disease 2006 5:6

    Content type: Focus

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  8. We discuss here some results which suggest that radically different maxicircle classes coexist within the same kinetoplast. These data, although tentative and incomplete, may provide a new outlook on the kinet...

    Authors: Pavel N Flegontov and Alexander A Kolesnikov

    Citation: Kinetoplastid Biology and Disease 2006 5:5

    Content type: Focus

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  9. This report focuses on the 2005 Annual meeting held in Caxambu, Minas Gerais, Brazil that was convened and organized by the Brazilian Society of Protozoology

    Authors: Jeffrey Shaw, Sergio Schenkman and Mauricio Martins Rodrigues

    Citation: Kinetoplastid Biology and Disease 2006 5:4

    Content type: Focus

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  10. African trypanosomes exert significant morbidity and mortality in man and livestock. Only a few drugs are available for the treatment of trypanosome infections and therefore, the development of new anti-trypan...

    Authors: Karin Merschjohann and Dietmar Steverding

    Citation: Kinetoplastid Biology and Disease 2006 5:3

    Content type: Original research

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  11. A nested polymerase chain reaction (nPCR)-based assay, was developed and evaluated for rapid detection of Trypanosoma evansi in experimentally infected mice and naturally infected camels (Camelus dromedarius). Fo...

    Authors: Imadeldin E Aradaib and Ali A Majid

    Citation: Kinetoplastid Biology and Disease 2006 5:2

    Content type: Original research

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  12. Leishmania parasites undergo profound morphological and biochemical changes while passing through their life cycle. Protein kinases have been shown to be involved in the differentiation from the extracellular fla...

    Authors: Qiong Wang, Inga M Melzer, Martin Kruse, Claudia Sander-Juelch and Martin Wiese

    Citation: Kinetoplastid Biology and Disease 2005 4:6

    Content type: Original research

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  13. Trypanosomosis is a major impediment to livestock farming in sub-Saharan Africa and limits the full potential of agricultural development in the 36 countries where it is endemic. In man, sleeping sickness is f...

    Authors: Musa O Ng'ayo, Zablon K Njiru, Eucharia U Kenya, Geoffrey M Muluvi, Ellie O Osir and Daniel K Masiga

    Citation: Kinetoplastid Biology and Disease 2005 4:5

    Content type: Original research

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  14. The direct agglutination test (DAT) has proved to be a very important sero-diagnostic tool combining high levels of intrinsic validity and ease of performance. Otherwise, fast agglutination screening test (FAS...

    Authors: Eduardo S Silva, Gerard J Schoone, Celia MF Gontijo, Reginaldo P Brazil, Raquel S Pacheco and Henk DFH Schallig

    Citation: Kinetoplastid Biology and Disease 2005 4:4

    Content type: Original research

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  15. Leishmania spp., in the course of their parasitic life cycle, encounter two vastly different environments: the gut of sandflies and the phagosomes of mammalian macrophages. During transmission into a mammal, t...

    Authors: Fanny Beatriz Zamora-Veyl, Manfred Kroemer, Dorothea Zander and Joachim Clos

    Citation: Kinetoplastid Biology and Disease 2005 4:3

    Content type: Original research

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  16. We evaluated the adoptive transfer of DCs on Leishmania (L.) mexicana-infected neonatal BALB/c mice. DCs were isolated and purified from the spleens of the following donor groups: a) Adult BALB/c mice infected du...

    Authors: Loida V Ponce, José Corado, Nilka L Díaz and Felix J Tapia

    Citation: Kinetoplastid Biology and Disease 2005 4:2

    Content type: Original research

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  17. In yeast and Caenorhabditis elegans, Silent Information Regulator (SIR2) proteins have been shown to be involved in ageing regulation. In Leishmania, the LmSIR2rp was originally isolated from the excreted/secrete...

    Authors: Denis Sereno, Laurent Vanhille, Baptiste Vergnes, Adriano Monte-Allegre and Ali Ouaissi

    Citation: Kinetoplastid Biology and Disease 2005 4:1

    Content type: Original research

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  18. Based on the recently sequenced gene coding for the Trypanosoma evansi (T. evansi) RoTat 1.2 Variable Surface Glycoprotein (VSG), a primer pair was designed targeting the DNA region lacking homology to other know...

    Authors: Filip Claes, Magda Radwanska, Toyo Urakawa, Phelix AO Majiwa, Bruno Goddeeris and Philip Büscher

    Citation: Kinetoplastid Biology and Disease 2004 3:3

    Content type: Original research

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  19. Chagas' disease caused by Trypanosoma cruzi is an opportunistic infection in the setting of HIV/AIDS. Some individuals with HIV and chronic T. cruzi infection may experience a reactivation, which is most commonly...

    Authors: Anil K Vaidian, Louis M Weiss and Herbert B Tanowitz

    Citation: Kinetoplastid Biology and Disease 2004 3:2

    Content type: Review

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  20. Trypanosoma rangeli is an important hemoflagellate parasite of several mammalian species in Central and South America, sharing geographical areas, vectors and reservoirs with T. cruzi, the causative agent of Chag...

    Authors: Cristiane Quimelli Snoeijer, Gisele Fernanda Picchi, Bibiana Paula Dambrós, Mário Steindel, Samuel Goldenberg, Stênio Perdigão Fragoso, Daniel Macedo Lorenzini and Edmundo Carlos Grisard

    Citation: Kinetoplastid Biology and Disease 2004 3:1

    Content type: Focus

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  21. Recently new aspects of the immunopathology of Chagas disease have been described in patients infected with HIV and unusual clinical manifestations such as cutaneous lesions, involvement of central nervous sys...

    Authors: Célia M Marques de Brito, Marize Q Pires and Raquel S Pacheco

    Citation: Kinetoplastid Biology and Disease 2003 2:17

    Content type: Original research

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  22. This paper is a commentary on "Species concepts for trypanosomes: from morphological to molecular definitions?" by Wendy Gibson published in this journal [1]. Taxonomy has been traditionally based on expert opini...

    Authors: Hooman Momen

    Citation: Kinetoplastid Biology and Disease 2003 2:13

    Content type: Focus

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  23. This paper summarizes the main results obtained on Trypanosoma cruzi genetic diversity and population structure since this parasite became the theme of many genetic and molecular studies in the early seventies.

    Authors: Michel Tibayrenc

    Citation: Kinetoplastid Biology and Disease 2003 2:12

    Content type: Review

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  24. Kinetoplastida are protozoan organisms that probably diverged early in evolution from other eukaryotes. They are characterized by a number of unique features with respect to their energy and carbohydrate metab...

    Authors: Véronique Hannaert, Frédéric Bringaud, Fred R Opperdoes and Paul AM Michels

    Citation: Kinetoplastid Biology and Disease 2003 2:11

    Content type: Review

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  25. Sporadic outbreaks of bovine trypanosomiasis have been reported in Bolivia since 1996 when T. vivax and T. evansi were identified for the first time by parasitological means. However, comprehensive epidemiologica...

    Authors: Jose Luis Gonzales, Tudor W Jones, Kim Picozzi and Hugo Ribera Cuellar

    Citation: Kinetoplastid Biology and Disease 2003 2:8

    Content type: Original research

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  26. One of the major differences between protozoan differentiation and metazoan differentiation is that protozoan cells normally retain potency during differentiation, which need not, therefore, be considered altr...

    Authors: Kevin M Tyler

    Citation: Kinetoplastid Biology and Disease 2003 2:2

    Content type: Editorial

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  27. The protozoan pathogen, Trypanosoma brucei, undergoes complex cycles of differentiation and multiplication in its vector, the tsetse fly, genus Glossina. Flies are refractory to infection and resistance mechanism...

    Authors: Wendy Gibson and Mick Bailey

    Citation: Kinetoplastid Biology and Disease 2003 2:1

    Content type: Original research

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  28. Cutaneous leishmaniasis (CL) is endemic in the Middle Eastern countries. New cases are emerging in areas previously free of the disease. In Jordan, the diagnosis of cases during the 1960s and 1970s was mainly ...

    Authors: Laila Nimri, Radwan Soubani and Marina Gramiccia

    Citation: Kinetoplastid Biology and Disease 2002 1:7

    Content type: Original research

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  29. A Leishmania model to explain microbial virulence in chronic infectious diseases is proposed. All these diseases progress from infection to symptomatic phase to host death or recovery. The outcome of each phase i...

    Authors: Kwang-Poo Chang and Bradford S McGwire

    Citation: Kinetoplastid Biology and Disease 2002 1:1

    Content type: Review

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