Patients received daily injections of low dose antimonial + killed vaccine for 10 days followed by 10 day rest (one cycle). After 4 cycles combined treatment cured all patients vs. 8% in low chemo alone. Combined treatment significantly reduced drug dose, cost and time to cure. The vaccine was registered in Brazil. Adopted from Machado-Pinto J. et al. Int. J. Dermatol. 41 :73-8, 2002. with permission from Oxon Blackwell Pub. http://blackwellpublishing.com.