Figure 4

A variation generation model based on gene conversion. (a) At generation '0', a (reference) native DNA sequence, g_i,0, encodes a amino acid sequence, Ag_i,0. The mutation of nucleotides generate a new sequence, g_i,1, at generation '1', which encodes a mutated amino acid sequence, Ag_i,1. This is achieved when a donor sequence, g_k,0, is randomly selected to provide a sub-sequence to g_i,0. The resulting mutated sequence at generation '0' encodes Ag_i,1. The variability of a gene i, g_i,j, at generation j, is estimated by measuring the difference between Ag_i,0and Ag_i,j. (b) A more detailed graphical illustration (at the DNA level) of the biological gene conversion model based on SDSA homologous recombination (adapted from [14]), which is computationally approximated by model summarised in (a).