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Figure 4 | Kinetoplastid Biology and Disease

Figure 4

From: In silico, biologically-inspired modelling of genomic variation generation in surface proteins of Trypanosoma cruzi

Figure 4

A variation generation model based on gene conversion. (a) At generation '0', a (reference) native DNA sequence, gi,0, encodes a amino acid sequence, Agi,0. The mutation of nucleotides generate a new sequence, gi,1, at generation '1', which encodes a mutated amino acid sequence, Agi,1. This is achieved when a donor sequence, gk,0, is randomly selected to provide a sub-sequence to gi,0. The resulting mutated sequence at generation '0' encodes Agi,1. The variability of a gene i, gi,j, at generation j, is estimated by measuring the difference between Agi,0and Agi,j. (b) A more detailed graphical illustration (at the DNA level) of the biological gene conversion model based on SDSA homologous recombination (adapted from [14]), which is computationally approximated by model summarised in (a).

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