Figure 1

Multiple-point mutation model. A (reference) input DNA sequence, gi,0, encodes an amino acid sequence, Agi,0, at generation '0'. Random selection and mutation of nucleotides generate a new sequence, gi,1, at generation '1', which encodes a mutated amino acid sequence, Agi,1. The variability of a gene i, gi,j, at generation j, is estimated by measuring the difference between Agi,0and Agi,j.