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Figure 13 | Kinetoplastid Biology and Disease

Figure 13

From: Consultative meeting to develop a strategy for treatment of cutaneous leishmaniasis. Institute Pasteur, Paris. 13–15 June, 2006

Figure 13

Immunotherapy of CL lesions in macaque monkeys. Systemic administration of oligo-deoxy-nucleotide (ODN) class D/A limits the size of lesions following an intradermal infection with L. major. Importantly, the reduced morbidity was not associated with a reduction in long-term immunity, as such treated macaques were still protected following a secondary challenge. This suggests a potential role for CpG ODN in L. major treatment. These findings support the development of clinical studies to assess the use of CpG ODN types D/A as immunoprotective and therapeutic agents. (From Flyn B. et al Infect.& Immun. 73:4948, 2005 with permission)

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Kinetoplastid Biology and Disease

ISSN: 1475-9292