Effect of Z-Phe-Ala-CHN
on the size of the lysosome of T. brucei bloodstream forms in vivo. Mice were infected and treated as described in the legend to Fig. 1. On day 5 p.i., trypanosomes were purified and processed for electron microscopy. Ultrathin sections of representative cells purified from mice treated with Z-Phe-Ala-CHN2 (a) and vehicle alone (b) are shown. Note the enlarged lysosome in the trypanosome exposed to Z-Phe-Ala-CHN2 compared with that in the short-stumpy form from control mice. fl, flagellum; fp, flagellar pocket; ly, lysosome, m, mitochondrion. Bar, 0.5 μm.