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Figure 2 | Kinetoplastid Biology and Disease

Figure 2

From: The cysteine proteinase inhibitor Z-Phe-Ala-CHN2 alters cell morphology and cell division activity of Trypanosoma brucei bloodstream forms in vivo

Figure 2

Effect of Z-Phe-Ala-CHN 2 on the size of the lysosome of T. brucei bloodstream forms in vivo. Mice were infected and treated as described in the legend to Fig. 1. On day 5 p.i., trypanosomes were purified and processed for electron microscopy. Ultrathin sections of representative cells purified from mice treated with Z-Phe-Ala-CHN2 (a) and vehicle alone (b) are shown. Note the enlarged lysosome in the trypanosome exposed to Z-Phe-Ala-CHN2 compared with that in the short-stumpy form from control mice. fl, flagellum; fp, flagellar pocket; ly, lysosome, m, mitochondrion. Bar, 0.5 μm.

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