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Table 1 IC50 values of iron chelators for bloodstream forms of T. brucei 427-221a and T. congolense STIB910, and for human myeloid leukaemia HL-60 cells, and IC50 ratios of cytotoxic to trypanocidal activities of the chelators.

From: In vitro growth inhibition of bloodstream forms of Trypanosoma brucei and Trypanosoma congolenseby iron chelators

Compound IC50 (μM) IC50 ratio
  T. brucei T. congolense HL-60 cells T. brucei/HL-60 T. congolense/HL-60
Deferoxamine 3.3 3.4 97.0 29.4 28.5
2,3-Dihydroxybenzoic acid 220 n.d. n.d n.d. n.d
Ethylenediamine-di-o-hydroxyphenylacetic acid 120 n.d. 325 2.7 n.d.
5-Sulfosalicylic acid >1000 * >1000 * >1000 * 1 1
Tropolone 12.5 18.7 6.2 0.5 0.3
5-Methyl-tropolone 15.7 20.0 31.1 2.0 1.6
2,2'-Bipyridine 46.2 67.0 28.3 0.6 0.4
2,4,6-Tris(2-pyridyl)-1,3,5-triazine 28.6 75.0 90.1 3.2 1.2
1,10-Phenanthroline 3.3 5.3 8.5 2.6 1.6
4,7-Diphenyl-1,10-phenanthroline 2.0 4.5 48.3 24.2 10.7
Bathocuproine 3.0 >10 * >10 * >3.3 1
8-Hydroxyquinoline 2.1 206 7.7 3.7 0.03
Dimethylglyoxime >100 * >100 * >100 * 1 1
Quercetin 16.3 62.6 >100 * >6.1 >1.6
  1. *The highest concentration tested.
  2. n.d., not determined.
  3. Cu1+ chelator.