Table 1 IC50 values of iron chelators for bloodstream forms of T. brucei 427-221a and T. congolense STIB910, and for human myeloid leukaemia HL-60 cells, and IC50 ratios of cytotoxic to trypanocidal activities of the chelators.
Compound | IC50 (μM) | IC50 ratio | |||
|---|---|---|---|---|---|
T. brucei | T. congolense | HL-60 cells | T. brucei/HL-60 | T. congolense/HL-60 | |
Deferoxamine | 3.3 | 3.4 | 97.0 | 29.4 | 28.5 |
2,3-Dihydroxybenzoic acid | 220 | n.d.† | n.d | n.d. | n.d |
Ethylenediamine-di-o-hydroxyphenylacetic acid | 120 | n.d. | 325 | 2.7 | n.d. |
5-Sulfosalicylic acid | >1000 * | >1000 * | >1000 * | 1 | 1 |
Tropolone | 12.5 | 18.7 | 6.2 | 0.5 | 0.3 |
5-Methyl-tropolone | 15.7 | 20.0 | 31.1 | 2.0 | 1.6 |
2,2'-Bipyridine | 46.2 | 67.0 | 28.3 | 0.6 | 0.4 |
2,4,6-Tris(2-pyridyl)-1,3,5-triazine | 28.6 | 75.0 | 90.1 | 3.2 | 1.2 |
1,10-Phenanthroline | 3.3 | 5.3 | 8.5 | 2.6 | 1.6 |
4,7-Diphenyl-1,10-phenanthroline | 2.0 | 4.5 | 48.3 | 24.2 | 10.7 |
Bathocuproine‡ | 3.0 | >10 * | >10 * | >3.3 | 1 |
8-Hydroxyquinoline | 2.1 | 206 | 7.7 | 3.7 | 0.03 |
Dimethylglyoxime | >100 * | >100 * | >100 * | 1 | 1 |
Quercetin | 16.3 | 62.6 | >100 * | >6.1 | >1.6 |