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Figure 1 | Kinetoplastid Biology and Disease

Figure 1

From: LmxMPK4, a mitogen-activated protein (MAP) kinase homologue essential for promastigotes and amastigotes of Leishmania mexicana

Figure 1

Alignment of LmxMPK4 from L. mexicana with various MAP kinase amino acid sequences. LmxMPK4, Leishmania mexicana MAP kinase 4 (GenBank accession number AJ293282; [6]); Trypanosoma brucei MAP kinase, TbMAPK2 (GeneDB accession number Tb10.70.2070; [10]); Trypanosoma cruzi MAP kinase (GeneDB accession number Tc00.1047053511299.70); Chlamydomonas reinhardtii MAP kinase (GenBank accession number BAB18271); Dictyostelium discoideum ERK1 (GenBank accession number U11077; [13]); Homo sapiens ERK2 (GenBank accession number CAA77753; [14]). Roman numerals I to XI indicate kinase subdomains. The kinase domain is located between the two inverted triangles (▼). Arrows (↓) mark the potential regulatory phosphorylation sites in the TXY motif at Thr190 and Tyr192, filled circles (●) indicate conserved amino acid residues it is not clear what you mean by conserved aa residues, and open circles (○) depict the residues of the phosphate anchor ribbon for ATP binding. The asterisks (*) show the residues of the P+1 specificity pocket. The open triangle (Δ) marks the invariant lysine residue (K59), which is essential for the phosphate transfer reaction. The CD-domain is shaded in light grey. Dashes indicate gaps introduced to optimize the alignment; dots represent identical residues. The carboxy-terminal peptide used to generate antibodies is underlined. (50), the terminal 50 amino acid residues of the Dictyostelium kinase have been omitted. Numbering corresponds to LmxMPK4.

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