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Table 1 Genes associated to drug resistance in Leishmania

From: Physiological consequences of drug resistance in Leishmaniaand their relevance for chemotherapy

Species Gene Resistance to Cross resistance Reference
L. amazonensis lamdr vinblastine adriamycin [73]
   vinblastine   
   doxorubicin   [39]
   actinomycin-D   
  KDNA pentamidine   [64]
  ribonucleotide    
  reductase hydroxyurea   [74]
  gene    
  NAGT tunicamycin   [51]
L. donovani ldNTt1.1 tubericidin   [41]
  ldmdr1 vinblastine puromycin  
    anthracyclins [40, 42]
   methotrexate   [43]
  IMPDH mycophenolic acid   [53]
L. enriettii lemdr vinblastine puromycin [37]
L. infantum H-circle methotrexate   [75]
L. major H-circle primaquine methotrexate [28]
   terbinafine   
  SQS1 terbinafine   
  SQS1 itraconazole   
  TOR tubericidin   [54, 63]
  TUB2 tubericidin   
  DHFR-TS antifolates   
  PTR1 antifolates   
L. tarentolae H-circle methotrexate   [23, 24]
  ltpgpA-E vinblastine   
   arsenite   [2527, 33]
   antimoniates   
  gsh arsenite   [57]
  Cyb antimycin-A   [70]
  DHFR-TS folates   
  Ltdth methotrexate   [31, 36, 52]
  PTR1    
L. tropica ltpgpE methotrexate   [76]
  ltmdr daunomycin   [38]