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Figure 2 | Kinetoplastid Biology and Disease

Figure 2

From: Physiological consequences of drug resistance in Leishmaniaand their relevance for chemotherapy

Figure 2

Physiological events associated with drug-resistance in Leishmania . The physiological events associated with drug-resistance in Leishmania include changes in P-gp expression, parasite infectivity (lipophosphoglycan, acid phosphatase and meta-1 expression), incorporation of metabolites fundamental for the parasite survival (folates and nucleosides), xenobiotics conjugation and extrusion (trypanothione and Cyb expression), intracellular metabolism (dihydrofolate reductase-thymidylate synthetase, N-acetylglucosamine-1-transferase and pterin transferase), host-parasite interaction (membrane fluidity) and parasite cell shape and promastigote-amastigote differentiation (tubulin phosphorylation). Black arrows indicate whether a given parameter is increased or decreased in the resistant parasite.

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