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Table 1 Plant-like enzymes and enzymes of possible cyanobacterial origin in Trypanosomatidae

From: Evolution of energy metabolism and its compartmentation in Kinetoplastida

Enzyme

Function in algae and plants

Location in alga or plants (Plastid or Cytosol)*

Function in trypano-somatid

Glycosomal location in trypanosomatid

Refs

Sedoheptulose-1,7-bisphosphatase (SBPase)

Calvin cycle

P

PPP?

+

 

Glucose-6-phosphate dehydrogenase (G6PDH)

PPP

C

PPP

+

74

6-Phosphogluconolactonase (6PGL)

PPP

P

PPP

+

74

6-phosphogluconate dehydrogenase (6PGDH)

PPP

P

PPP

 

156

Fructose-1,6-bisphosphate aldolase (ALD)

Calvin cycle

P

glycolysis

+

157, 158

Glyceraldehydephosphate dehydrogenase (GAPDH)

Calvin cycle

C

glycolysis

+

134, 159

Phosphoglycerate kinase (PGK)

Calvin cycle

P

glycolysis

+

38

Phosphoglycerate mutase (PGAM)

glycolysis

C

glycolysis

 

41

α-Hydroxyacid dehydrogenase (AHADH)

glyoxylate cycle

C

aromatic amino-acid metabolism

 

160

Glycerol-3-phosphate dehydrogenase (G3PDH)

glycerol metabolism

P

glycerol metabolism

+

161

Alternative oxidase (AOX)

respiration

mitochondrion

respiration

 

162

Aconitase

Krebs' cycle

C and mitochon-drion

Krebs' cycle

 

23

Vacuolar-H+-pyrophosphatase (V-H+-PPase)

H+ pump

vacuole

H+ pump

 

163

ω-6-Fatty-acid desaturase

fatty-acid synthesis

ER?

fatty-acid synthesis

 

164

Superoxide dismutase (SOD)

ROS protection

P

ROS protection

+

 

Acyl carrier protein (ACP)

fatty-acid synthesis

P

fatty-acid synthesis

 

165, 166

Adenylate kinase (ADK)

energy balance

P

energy balance

+

 
  1. *Several enzymes, while of plastid or cyanobacterial origin, are found in the plant or algal cytosol. For example, the glycosomal trypanosomatid GAPDH and its cytosolic counterpart from Euglena gracilis are close relatives of the GAPDH isoenzyme 1 from cyanobacteria [134]. Interestingly, this isoenzyme is clearly distinct form the plastid GAPDH of plants, which has been derived from the cyanobacterial isoenzyme 3 [59]. Modified from [22]. Abbreviations: PPP, pentosephosphate pathway; ER, endoplasmic reticulum; ROS, reactive oxygen species. Supplementary material is available at: http://www.icp.ucl.ac.be/~opperd/Supplementary/table.html