From: Physiological consequences of drug resistance in Leishmaniaand their relevance for chemotherapy
Species | Gene | Resistance to | Cross resistance | Reference |
---|---|---|---|---|
L. amazonensis | lamdr | vinblastine | adriamycin | [73] |
 |  | vinblastine |  |  |
 |  | doxorubicin |  | [39] |
 |  | actinomycin-D |  |  |
 | KDNA | pentamidine |  | [64] |
 | ribonucleotide |  |  |  |
 | reductase | hydroxyurea |  | [74] |
 | gene |  |  |  |
 | NAGT | tunicamycin |  | [51] |
L. donovani | ldNTt1.1 | tubericidin | Â | [41] |
 | ldmdr1 | vinblastine | puromycin |  |
 |  |  | anthracyclins | |
 |  | methotrexate |  | [43] |
 | IMPDH | mycophenolic acid |  | [53] |
L. enriettii | lemdr | vinblastine | puromycin | [37] |
L. infantum | H-circle | methotrexate | Â | [75] |
L. major | H-circle | primaquine | methotrexate | [28] |
 |  | terbinafine |  |  |
 | SQS1 | terbinafine |  |  |
 | SQS1 | itraconazole |  |  |
 | TOR | tubericidin |  | |
 | TUB2 | tubericidin |  |  |
 | DHFR-TS | antifolates |  |  |
 | PTR1 | antifolates |  |  |
L. tarentolae | H-circle | methotrexate | Â | |
 | ltpgpA-E | vinblastine |  |  |
 |  | arsenite |  | |
 |  | antimoniates |  |  |
 | gsh | arsenite |  | [57] |
 | Cyb | antimycin-A |  | [70] |
 | DHFR-TS | folates |  |  |
 | Ltdth | methotrexate |  | |
 | PTR1 |  |  |  |
L. tropica | ltpgpE | methotrexate | Â | [76] |
 | ltmdr | daunomycin |  | [38] |